Siva Jyothi. J1*, Sujatha. S2, Jyothi .N 3, Rami Reddy. G4, Kishore Kumar. K5
1.Department of Pharmaceutics, St. Ann’s College of Pharmacy, Chirala-523 155
2.Department of Pharmaceutics, Narayana Pharmacy College, Nellore-524 002
3.Department of Pharmaceutical analysis, Shadan College of pharmacy for women, Hyderabad-500 004.
4.General manager Aurobindo Pharma Limited, The Water Mark Building, Kondapur, Hitech City, Hyderabad- 500 084
5.Department of Pharmaceutics, Malla Reddy College of Pharmacy, Hyderabad-500 100
The aim of the present work is to develop a pH and time dependent pulsatile release tablets of Meloxicam for delivering the drug into colon. The system consists of a drug containing core, coated by a combination of natural polymer locust bean gum and hydroxy propyl methyl cellulose (HPMCK100M) in various proportions to control the onset of release. The whole system was coated with Methacrylic acid copolymers to prevent the drug release in stomach and also to prolong the lag time. Meloxicam was used as a model drug and varying combinations of locust bean gum and HPMCK100M were used to achieve the desired lag time before rapid and complete release of drug in colon takes place. It was observed that the lag time depends on the coating ratio of LBG and HPMC and also on press coating weight. The drug release was to be increased by 15-30% in the presence of colonic microbial flora. The present study demonstrates that the Meloxicam enteric coated tablets could be successfully formulated as a pulsatile drug delivery by the design of a time and PH dependent Chronotherapeutic formulation.
Keywords: Pulsatile drug delivery, Meloxicam, Locust bean gum, Chronotherapeutics, hydroxy propyl methyl cellulose, Methacrylic acid copolymers, press and enteric coated tablets.