AJPHR

American Journal Of Pharmacy And Health Research

ISSN NO.: 2321-3647
September 2020 Issue 9
1

A Prospective Study Of Prescription Pattern and Assessing the Psychiatric Co-Morbidities In Dementia Patients In A Tertiary Care Hospital In South Kerala

Neethu J1*, Aranya K Sreekumar1, Jibin John1, Kavya Shyam1, Reshma S Reghu2 , Prasobh GR3

1.Associate professor, Department of pharmacy practice, Sreekrishna college of pharmacy and research centre, Thiruvananthapuram, Kerala, India

2. Fifth year Pharm D students, Sreekrishna college of pharmacy and research centre, Thiruvananthapuram,Kerala, India

3. Principal ,Head Of Department of pharmacy practice, Sreekrishna college of pharmacy and research centre, Thiruvananthapuram, Kerala , India

ABSTRACT

Dementia is one of the most common disorders among elderly patients, Worldwide 7.7 million new cases of dementia were anticipated each year, implying one new case every 4.1 seconds. The aim of the study is to assess the psychiatric co morbidity and prescribing pattern in a tertiary care hospital in south India. This was an Prospective Observational Study conducted at tertiary care hospital. Prospective data was collected from outpatient and inpatient department. Out of 16 patients the common type of dementia reported was Alzheimer’s disease found in ,56.3% of the cases followed by vascular dementia and the prescribed drugs were Memantine (37.5%) is the prescribed drug for most of the dementia cases followed by donepezil (25%), Memantine + donepezil combination (18.75%), Rivastigmine (12.5%), Memantine + Rivastigmine combination  (6.2%). The common type of dementia reported was Alzheimers and Memantine was the most commonly prescribed drug in mono-therapy and among combination therapy Memantine–donepezil combination was mostly prescribed.

Keywords: dementia, prescribing pattern, psychiatric co morbidity

2

New Drug and Clinical Trial Rules 2019: Paradigm Shift in Indian Pharmaceutical Industries

Manish Dagar1*, Khushboo Sharma2, Ajay Kumar2

1. Delhi Pharmaceutical Sciences & Research University, New Delhi-110017.

2.Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi-110062

ABSTRACT

The government notified the New Drugs and Clinical Trial Rules on 19th March 2019, to replace Part XA and Schedule Y of the Drugs and Cosmetics Rules 1945. Many new desirable changes have been made and these will help clinical research and trials in India. However, there are discrepancies which offset some of the advantages offered by the new rules. Including timelines for many regulatory functions, is among the main advantages offered, but incorrect use of terms, duplication of rule numbers is likely to complicate the regulatory procedures. The changed classification of Ethics Committees is a welcome feature, but it is unclear why the composition recommended by ICMR is accepted for the EC for Biomedical and Health Research, but not for the one for Clinical Trials, Bioavailability and Bioequivalence Studies. The government would do well to consider the suggestions made herein and amend the New Drugs and Clinical Trial Rules 2019.

Keywords: New Drugs, Clinical Trials, Ethics Committee, Compensation, Amendments.        

3

Unani Formulation for Conservative Treatment of Cholecystitis: An Observational study.

    Md Reyazuddin1, Mohammad Ali2, Md Tanwir Alam3*

1.PG Scholar, Dept. of Ilmul Jarahat, DUMC Hospital & Research Centre, Deoband, U.P.

2.Professor, Dept. of Ilmul Jarahat, DUMC Hospital & Research Centre, Deoband, U.P.

3.Assistant Professor, Dept. of PSM, Govt. Tibbi College & Hospital, Patna, Bihar.

ABSTRACT

In Unani system of medicine Sharbat Bazoori Motadil and Majoon Dabedulward are compound formulation is effective in the treatment of Amraz-e- Jigar and may be useful in the treatment of Cholecystitis also. So, the aim of this study is to evaluate the efficacy of Unani Formulation on scientific parameters. This study was an open observational study, carried out on 40 patients. The test drug was given in the form of decoction with 7 gm Majoon Dabidul Ward with 50 ml Sharbat Bazoori Moatadil twice a day after meal for the period of 2 months. All the patients of were assessed fortnightly on subjective parameters (0th, 15th, 30th 45th and 60th day) whereas objective parameters were assessed before and after the treatment. The outcome of intervention was analyzed using appropriate statistical methods. Subjective parameters were satisfactorily alleviated by the test drugs. Findings suggest the effectiveness of test drug in Cholecystitis. Subjective parameters and the findings in USG and CT scan ere also improved.

Keywords: Majoon Dabidul Ward; Sharbat Bazoori Moatadil; Cholecystitis; Warm-e-Marara.

4

A Prospective Open Label Randomized Clinical Study of Compound Unani Formulation (Ustukhuddoos, Filfil Siyah, Aslussoos) in the Management of Iltihab-e-Tajaweef-e-Anaf Muzmin (Chronic Sinusitis).

Md Zahid Arfi1, Md Razi Ahmad2 Md Najibur Rahman3, *Md Tanwir Alam4.

1.PG Scholar, Dept. of Moalajat, ZVM Unani Medical College & Hospital Pune.

2.Assistant Professor, Dept. of Niswa wa Qabalat, Govt. Tibbi College & Hospital, Patna.

3.Assistant Professor, Dept. of Moalajat, Govt. Tibbi College & Hospital, Patna.

4.Assistant Professor, Dept. of PSM, Govt. Tibbi College & Hospital, Patna.

ABSTRACT

Tajaweef-e-Anaf (Sinusitis) has tremendous impact on public health. It is the 5th known case of population16,17. Under such circumstances, the Unani medicine has proven its own importance regarding its efficacy, cost and minimal side effects. The present study was designed as an open label randomized clinical trial in successive patients with chronic sinusitis diagnosed on presentation, history and investigations. Sixty diagnosed patients of age between 15-60 years. Who belongs to inclusion criteria were registered, and compound Unani formulation (Ustukhuddoos, Filfil Siyah, Aslussoos) is given for 45 days. Complete physical examination & investigations of patients were done and follow-up planned prior of trial, 15th 30th day and at the end of trial. Subjective objective and safety parameter recorded. On objective parameters, there are two sub headings, pathological investigation and radiological examination. In Radiological examination, Calculating by Chi-square p-Value is 0.001 which is significant. While in pathological investigation in TLC, Lymphocyte, Eosinophils “P” value is 0.001, which is very significant. Haemoglobin “P” value is 0.517 and Monocyte, “P” value 0.088 which is not significant.

Keywords: Tajaweef-e-Anaf; Ustukhuddoos; Filfil Siyah; Aslussoos; Unani Medicine.

5

Management of Obesity through Luk Maghsul, Ajwain Desi and Zeera Siyah: A Randomized Trial

      Sayyed Juwairiyah1, Md. Razi Ahmad2, Md Najibur Rahman3, Md Tanwir Alam4*.

1.PG Scholar, Dept. of Moalajat, ZVM Unani Medical College & Hospital Pune. 

2. Assistant Professor, Dept. of Niswa wa Qabalat, Govt. Tibbi College & Hospital, Patna.

3.Assistant Professor, Dept. of Moalajat, Govt. Tibbi College & Hospital, Patna, Bihar.

4.Assistant Professor, Dept. of PSM, Govt. Tibbi College & Hospital, Patna, Bihar.

ABSTRACT

Obesity is an independent risk factor for cardiovascular disease (CVD). Obesity is associated with an increased risk of morbidity and mortality as well as reduced life expectancy. The last two decades of the previous century have witnessed dramatic increase in health care costs due to obesity and related issues among children and adolescents. The emerging epidemics of obesity, CVD and diabetes form the crux of this phenomenal change. Among these entities, obesity has become a colossal epidemic causing serious public health concern and contributes to 2.6 million deaths worldwide every yearr. The open label randomized clinical trial on 60 diagnosed patients of obesity, aged between 20-50 years. An Unani formulation -compound of Luk Maghsul (Tachardia Laccca),Ajwain Desi (Trachyspermum ammi) & Zeera Siyah (Carum carvi) is given for 90 days. The “P” value of each intervention groups on all parameters is P= 0.001.

Keywords: Samane Mufrit; Luk Mughsul; Ajwain Desi; Lac; Zeera Siyah.

6

Diuretic Activity of Some Known Medicinal Plants: A Review

Aswini EV*, Vivek D ,Swathilakshmi S

College of Pharmaceutical Sciences, Government Medical College, Pariyaram, Kannur- 670503

ABSTRACT

Diuretics are one of the important class of drugs, act within the kidney and promote the loss of fluid from the body. Mechanism behind diuretics is compound interfere with the reabsorption of electrolytes their by promote sodium, potassium, chloride excretion in the body. Now adays herbal medicine use becoming popular due to toxicity and side effects of allopathic medicines. Diuretic activity study mainly conducted in animals. Most commonly preferred in vivo method is Lipschitz method. Rats or mice are the most commonly used animals. Diuretic activity study concluded that majority of plant extract possess diuretic activity similar to standard drugs like furosemide and hydrochlorothiazide. Diuretic activity determined by measuring urine volume, osmolarity, concentration of electrolytes, and pH. This review summarizes the herbal medicine used as diuretics and their botanical characteristics, ethnobotany, distribution and diuretic activity study. This review provide knowledge regarding surrounding herbal medicine used as diuretic and their significance in quality of life.

Keywords: Diuretics, Herbs, Ethnobotany, Medicinal plants, Diuretic activity