The review on drug targeting in neoplastic disorders emphasizes the various targeting techniques for  effective treatment of the condition. Neoplasm refers to the new growth and its common in any individual, uncontrolled neoplasm results in condition called neoplastic disorder or tumor or cancer. Globally 14.1 million cancer cases were reported in 2012 and the number is expected to reach 24 million by 2035. This review outlines the advances in drug targeting to the neoplastic disorders  keeping in view on the highlights the novel drug delivery systems like liposomes and particulate system like nanoparticles  problems associated with conventional chemotherapy and radiation therapy. It usage in treatment of cancer and effective targeting ways to target the tumor cells without affecting the normal cells.