ABSTRACTThe ultimate aim of present work was to prepare formulation of poly-herbal soap from extract of tulsi leaves, aloe-vera leaves, vitamin E capsules and honey using glycerine soap base by melt and pour method. The formulation was evaluated for physicochemical parameters like appearance, pH, sensitivity test, foaming test, stability test. All evaluation parameters results were positive and comply with standard values. Therefore, these plant materials can be used in the preparation of herbal soap on commercial scale for acne treatment. Keywords: Polyherbal Soap, plant material, acne.