ABSTRACTMedicinal mushrooms have been used in traditional medicine for a long time due to their various health benefits, particularly in wound healing. This article delves into their capabilities in healing wounds, with a specific focus on important bioactive components like chitin and chitosan, polysaccharides, and the transition from ethnobiology to ethnopharmacology. Recent progress in comprehending the wound-healing properties of medicinal mushrooms emphasizes the significance of chitin and chitosan, which are abundant in the cell walls of fungi. These compounds possess antimicrobial, anti-inflammatory, and immunomodulatory effects, which aid in wound closure, reducing infection rates, and promoting tissue regeneration. The combination of these bioactive molecules with other substances found in mushrooms presents promising opportunities for future wound-healing therapies. The integration of traditional knowledge and scientific research highlights the potential of medicinal mushrooms in the development of innovative and effective treatments for wound healing. Ongoing investigation into the mechanisms and applications of these bioactive compounds holds great promise for advancing wound care. Keywords: Mushroom, chitin and chitosan, polysaccharides, ethnobiology, ethnopharmacology, and wound healing