ABSTRACTPavetta corymbosa (Rubiaceae) is a plant traditionally used in sub-Saharan Africa for the treatment of pathologies such as malaria, pain, diabetes, hemorrhages, bacterial infections and typhoid fever. However, there is no scientific information on its analgesic potential, hence the interest of this study which is to evaluate the analgesic potential of the leaves of this plant which would justify its use in traditional medicine. The analgesic effect of the aqueous and hydroethanolic extracts of Pavetta corymbosa at doses of 200 mg / kg of body weight was evaluated by the injection of acetic acid 1% to mice in comparison with paracetamol (reference analgesic) at a dose of 150 mg / kg. The results showed that aqueous and hydroethanolic extracts significantly reduced abdominal contortions in mice (p < 0.05). However, the analgesic effect of both types of extracts is comparable to that of paracetamol. Hence the interest in its use in traditional medicine against certain pathologies. Keywords: Pavetta corymbosa, analgesic, aqueous extract, hydroethanolic extract.