Wounds are major responsible for physical disabilities. Wound disease spread by the invasion of bacteria inside the body through skin. Most of pathogenic microorganisms responsible for wound include Staphylococcus aureus, Streptococcus pyogenes, Enterococci, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa. Bacterial infections on skin are the common ailment for generation of other diseases in the body. Wound infections represent the invasion of tissues by number of species of microorganisms. These infections disturb the immune system of body and cause delayed wound healing. Aloe vera leaves pulp is used for medicinal purposes, including treatment of constipation, asthma, diabetes, peptic ulcer, inflammation, wound healing, heart burn, heat stroke etc. While Azadirachta indica is useful in tiredness, cough, fever, loss of appetite, worm infestation. It heals wound, heat-rash, boils, jaundice, leprosy, skin disorders, eye disorders, stomach ulcers, chicken pox, excessive thirst, diabetes and insect poisons. It act as anti-leprotic, antimalarial, anti-hemorrhoidal and anthelmintic agent. The present study was undertaken on evaluation of combinational effect of ethanolic extract of Aloe vera leaves pulp and Azadirachta indica leaves for wound healing activity through topical route on excision wound model. The activity was compared with standard drug Povidone Iodine ointment(5% w/w). Combinational effect of both extract was showed faster wound healing effect than standard drug Povidone Iodine ointment on excision wound model.