ABSTRACTThe genus Artocarpus belongs to the family Moracea which comprises of about 60 genera and over 1000 species. Artocarpus species are known for its edible fruit with high nutritive values. Artocarpus hirsutus Lam. is one among the five available varieties of jackfruits. The aim of the present study is to evaluate hypocholesterolemic effect on roasted and non roasted seeds of Artocarpus hirsutus. The current study was designed to examine the cholesterol lowering activity of A. hirsutus seed extracts in hyperlipidemic rat model induced with 25% fat rich diet and details of parameters associated with hyperlipidemia (Cholesterol, Triglycerides, HDL & LDL and serum marker enzymes) were assessed. Treatment of hypercholesterolemic rats with A. hirsutus seed extracts induced marked significant decrease of serum total cholesterol, triglycerides and LDL- cholesterol concentrations as compared to the hypercholesterolemic rats. Keywords: Artocarpus Hirsutus, Hypocholesterolemic.