2-amino-6-fluoro-7-chloro (1,3) benzothiazoles is treated with six different aldehydes to get six different Schiff’s base (Azomethine) in presence of ethanol and HCl, then all the Schiff’s bases are separately refluxed with thioglycolic acid in presence of the solvent dioxane and triturated with NaHCO3 solution, as six different parent compounds. The resulted six azomethine (Schiff’s base) are treated with chloro acetyl chloride, triethylamine in presence of dioxane results gives six different, the parent compounds were treated with various aromatic primary and secondary amines in presence of Dimethyl formamide (DMF) gives various derivatives. Further, they have been screened for their antimicrobial, antiinflammatory (in-vitro and in-vivo) anticonvulsant and anthelmintic activity by standard method. Keywords; Fluorine, Schiff’s base, Thiazolidinone and Azetidinone