The increasing resistances to several antibiotic classes have forced pressures on fluoroquinolones (FQs) use. Even among FQs, resistances are growing due to rapid spreading of adaptive measures. We investigated Staphylococcus aureus urinary tract infections (UTIs) to understand its infectivity patterns, sensitivity trends to FQs, multi-fluoroquinolone resistant patterns, and fluoroquinolones’ interactivity relations from January 2005 to December 2009. 211 (13.3%) Staphylococcus aureus were isolated from 1590 urine cultured samples having its peak infectivity in 2006 with 28.4% and least proportion (10.9%) in 2005.  Staph aureus UTIs were higher in women (41.7%) than men (20.4%) in those between 10 and 30 years, but beyond this age range, this trend was reversed (16.6% for men and 3.3% for women). The overall activities of the FQs during the 5 years periods range from 41% in norfloxacin to 85% in ofloxacin and resistance rates of the pathogen have out-grown sensitivity for norfloxacin and nalidixic acid. Age dependent increase in resistance was correlated for ciprofloxacin (P=0.003) and norfloxacin (P