A simple, accurate, precise and fast reverse phase, gradient RP-HPLC method was developed for the separation of telmisartan and hydrochlorothiazide in combination dosage form of Tablets. The method was carried out by using Kromasil, C18, 4.6 x 150mm, 5 μm enhanced polar selectivity column and mobile phase comprised of potassium dihydrogen phosphate buffer pH adjusted to 3.2 ± 0.5 with orthophosphoric acid and acetonitrile, and degassed under ultrasonication. The flow rate was 1.5 mL/min and the effluent was monitored at 225nm. The retention time of hydrochlorothiazide and telmisartan were 2.7 ± 0.5 and 7.3 ± 0.5 respectively. The method was validated as per ICH guideline. The proposed method is suitable for simultaneous determination of telmisartan and hydrochlorothiazide in pharmaceutical dosage form.