Current study endeavored to examine the microbiological quality as well as the anti-bacterial traits of different sterile liquid drops commonly applied for the treatment of eye and ear infections in Bangladesh. Fifteen (15) different types of liquid drops manufactured in different pharmaceutical industries were microbiologically examined through common, traditional and replicable cultural and biochemical tests. Total viable bacterial and fungal load (~101 -104 cfu/ml) showed repugnant contamination of which 7 samples significantly exceeded United States Pharmacopeia (USP) or British Pharmacopeia (BP) limit (