The aim of the present study is to evaluate the effect of aqueous extract of Leptadaenia reticulata for immunomodulating activity. The aqueous extract of plant of Leptadaenia reticulata holds potential as a protective agent against cytotoxic drugs. The extracts when studied on humoral and cell mediated immunity in normal, as well as cyclophosphamide induced immunosuppressed rats, it produced an increase in carbon clearance, humoral antibody (HA) titre, delayed type hypersensitivity (DTH) and white blood cell (WBC) count in a dose dependent manner. The aqueous extract also enhanced interleukin-2 (IL-2) level in a dose dependent manner while the IL-6 showed almost stable level. The present investigation established pharmacological evidence to support the folklore claim that it is an immunomodulating.