American Journal of Pharmacy and Health Research AJPHR 2321-3647 AJPHR203005 Synthesis and Biological study of Substituted 1, 2, 4-Triazolines and their acetyl derivatives Bhaskar Chandrakant Makode Jagannath Berad Baliram Department of Chemistry,Art’s, Commerce and Science College, Koradi (Nagpur)-441111(MS) Department of Chemistry, Shri Shivaji College of Art’s, Commerce and Science, Akola-444101(MS) Post Graduate Department of Chemistry, RTM Nagpur University, Nagpur-440033. (MS) 03 01 2014 2 3

In the reaction of isoniazid with different aldehydes the respective N1-((un)-substituted benzilidene) isoniazid derivatives were obtained. Further reaction with N1-((un)-substituted benzilidene) isoniazids and hydrazine hydrate yielded dihydroformazans. These dihydroformazans on reaction  with N-phenylisocynodichloride in chloroform medium led to the creation of 1, 2, 4-triazolines. All these 1,2,4-triazolines were further converted into their acetyl derivatives by reacting them with acetic anhydride. The structures of all new compounds were confirmed by using elemental and spectral analysis. All the compounds were screened for their antifungal activities.

 1 2 4-Triazolines Dihydroformazans Synthesis of 1 2 4-triazolines.