The present study is aimed to evaluate antioxidant and anti arthritic activity of polyherbal formulation. The polyherbal formulation composed of six medicinal plants namely Asparagus racemosus, Allium sativum, Bacopa monneri, Lippia nodiflora, Smilax zeylanica, Oldenlandia heynei. anti oxidant activity  by using Reducing power assay, Nitric oxide scavenging assay and anti-arthritic activity by using inhibition of protein denaturation, inhibition of protenase enzyme activity, membrane stabilization. Diclofenac sodium was used as a standard drug. Key words: Polyherbal formulation, anti-arthritis and anti- oxidant.