Different antibiotics were selected, two local brands and one multinational brand for the same antibiotic so that comparison will be quite easy. Antibiotics used during the research work were Ofixime (Cebosh, Megnet, Fixitile), Paramycin (Nebra, Eyebrex, Tobracin), Emoxicillin (Supramox, Polyxil, Ospamox). These antibiotics were checked for their potential as antibacterial agents against some gram positive and gram negative bacterial strains, by agar well diffusion method. Antibacterial activity was deliberated against five bacterial strains i-e Klebsiella pneumonia, E.Coli, Salmonella, Staphylococcus Aureus and Flavobacterium Aureus.