The objective of the study of antipyretic effect of ethanolic extract of flowers of Artabotrys hexapetallus tested on yeast induced pyrexia in albino rats. The flower extract at oral doses of 100, 250 and 500 mg/kg has been used to investigate the antipyretic potential of flowers extract. At a dose of 500 mg/kg body weight showed significant reduction in body temperature on yeast induced pyrexia when compared to standard drug Paracetamol (200 mg/ml).