To evaluate the liver and kidney function status of Type ll Diabetic patients. In the present research work on type II diabetes mellitus, various biochemical parameters have been analyzed in a systematic manner. Blood samples were collected from Sun and Apollo laboratory in Coimbatore. About thirty type ll diabetic patients (age : 40 – 70, 15 males and 15 females) and thirty normal individuals (age 30 – 50, 17 males and 13 females) were selected. Among with elevated blood sugar level, serum creatinine, urea, uric acid and protein were also significantly increased. Significantly increased levels of AST and ALT were observed in diabetic, when compared to normal control. The present study suggests that an elevation of blood glucose level might precede the development of liver diseases and renal problems in patients with type ll diabetes mellitus. In conclusion, the hyperglycemic patients were also observed the elevated levels of liver function enzymes and blood metabolites like urea, creatinine and uric acid.