Microwave  assisted organic reaction enhancements (MORE) is a simple, clean, fast, efficient, economic and environment friendly method for the synthesis of 4- piperidones. The aim of this article is to synthesize characterize and evaluate the antimicrobial activity of certain novel thiazole compounds. The synthesized compounds were characterized by elemental analysis and IR, NMR and mass spectral data. All compounds were found to exhibit a fair degree of antimicrobial activity.