In the era of technology, when the manufacturing of Ayurvedicdrugs become the part of industrial business, then the standard parameters to check the market quality of drugs should be necessary then and then by the invincible Ayurvedicscience, treatment will be found efficacious. Present work had been carried out to analyzethe Nimbadi yoni vartifor their Physico-chemical parameter. The present study will assist in standardization for quality, purity and sample identification. Various standardization parameters like morphological characters, microscopic evaluation, physicochemical evaluations, preliminary phytochemical screening and TLC chromatographic profile of the drug were carried out and the qualitative parameters were reported. Pharmacognostical and phyto-chemical observations revealed the specific characters of all active constituents used in the preparation. The presence of tannin, fibers, sclerides, stone cells and calcium oxalate crystals were the characteristic features observed in the microscopy of drug combination. Phyto-chemical analysis showed that average weight  ofvarti is 3.5gm, disintegration time 1 hrs, pH 5.0, water soluble extract 36.88% w/w , Methanol soluble extract 4.212% w/w, Ash value 3.95% w/w, Loss on drying 33.84% w/w.Qualitative analysis showed the presence of alkaloids, tannins, flavonoids, saponins and anthraquinon glycosides. These studies provide referential information for correct evaluation and standardization of the Nimbadi yoni varti.