The mast cell and cough has long been associated with asthma, since it releases a variety of preformed and newly synthesized mediators that account for several features of asthma. Among the mediators, histamine is a well characterized and the most potent vaso-active mediator in acute broncho-constriction. The present study was carried out to evaluate In vitro and In vivo mast cell stabilizing and anti-tussive activity of ethyl acetate and methanolic extract of fruit of Piper lignum