Modern technology advancement, increasing population and human need to this technology causes problems such as environmental pollution, especially air pollution. However, the critical situation of air pollution in Tehran is obvious and since the pharmaceutical industries considered as one of the main industries in Tehran, this study focuses on air pollution in two pharmaceutical industries during 2009 to 2013 in the eastern and western regions of Tehran and comparing with the global standard. The results indicate that Aburaihan pharmaceutical company shows more pollution than other one, which more likely is due to its proximity to Tehran’s major highways.