Bilayer tablet is new era for the successful development of controlled release formulation and also provide a successful key for other drug delivery system. Bilayer tablet is made up of two layers in which one is immediate layer for initial dose and second layer is sustained layer for maintenance dose. Thus, bilayer tablet is useful for sequential release of two drugs in combination and is applicable for improved patient compliance and mainly for reduced toxicity. It is useful for both single and multiple dose therapy. The present article gives an idea about an introduction of bilayer tablet, various tablet presses, manufacturing process, GMP and quality requirements, and challenges in bilayer tablet and recent approach in bilayer tablet development.