The mark of an astute clinician is his ability to resolve patients discomfort and strive for complete patient satisfaction. This however becomes tough while providing dental care since patients already may have an instilled fear of dental treatment when they visit a dental practioner. Such fear and apprehension arises due to anticipation of pain during dental procedures. While treating endodontic infections, an important aspect is to provide adequate pain relief. Operative procedures may provide eventual healing of infection but post operative pain might still persist. Therefore adjunctive use of pharmacologic strategies is often required. This review article aims to outline various pharmacologic treatment approaches in resolving pain associated with endodontic cases.