A rapid, specific reversed phase HPLC method has been developed for simultaneous determination of pantoprazole and levosulpridein their formulations. Chromatographic separation of these two pharmaceuticals was carried out on an Aligent,Zorbax column (250mmx4.6mm, particle size 5μm)with a 600:4000 (v/v/v) mixture of Potassium dihydrogen orthophosphate (pH-3.0; 0.01M)  buffer adjusted with Ortho phosphoric acid and methanol as mobile phase. The flow rate 1.0mL.min-¹ and the analytes are monitored at 230nm.The assay results were linear from 240-720μg/mL for pantoprazole(r ² >= 0.9999) and 450-1350μg/mL for levosulpride (r ² >= 0.9999), showed intra- and inter-day precision less than 2.0%, and accuracy of 100%.The LOD was 0.00321 and 0.000549μg.mL-¹ for pantoprazole and levosulpride respectively. Separation was complete in less than 5 min. Validation of the RP-HPLC method showed to be robust, precise, accurate and linear over the range of analysis.