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  <front>
    <journal-meta>
      <journal-title-group>
        <journal-title>American Journal of Pharmacy and Health Research</journal-title>
        <abbrev-journal-title abbrev-type="publisher">AJPHR</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="epub">2321-3647</issn>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">AJPHR212019</article-id>
      <title-group>
        <article-title>Development and In-Vitro Evaluation of Bilayer Elementary Osmotic Tablet of Verapamil Hydrochoride</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Nirmal</surname>
            <given-names>Sancheti Vikram</given-names>
          </name>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Ashok</surname>
            <given-names>ChordiyaMayur</given-names>
          </name>
          <xref ref-type="aff" rid="aff2"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Senthilkumaran</surname>
            <given-names>K.</given-names>
          </name>
          <xref ref-type="aff" rid="aff3"/>
        </contrib>
      </contrib-group>
      <aff id="aff1">Department of Pharmaceutics, Padmavathi College of Pharmacy &amp; Research Institute, Dharmapuri, Tamil nadu, India.</aff>
      <aff id="aff2">Department of Pharmaceutics, SNJBs SSDJ College of Pharmacy, Chandwad, Nashik, India.</aff>
      <aff id="aff3">Department of Pharmaceutics, K.K. College of Pharmacy, Chennai, India.</aff>
      <pub-date pub-type="epub" iso-8601-date="2014-12-01">
        <month>12</month>
        <day>01</day>
        <year>2014</year>
      </pub-date>
      <volume>2</volume>
      <issue>12</issue>
      <abstract>
        <p>The purpose of this study was to develop a bilayer elementary osmotic tablet of Verapamil Hydrochloride. The drug candidate selected under the study is Verapamil hydrochloride, a calcium channel blocking agent used in the treatment of angina pectoris, hypertension and cardiac arrhythmia. Verapamil Hydrochloride has a short elimination half-life; this will bring down its dosing frequency to once a day and on the same time make a zero order release system. Tablets were prepared by using controlled release polymers. The formulations were evaluated for pharmacopoeial quality control tests and all the physical parameters evaluated were within the acceptable limits. Formulation B12 was proved to be good drug content, dimensional stability and drug release up to 24 h as compared to the other formulations. Stability studies were carried out on the optimized formulationB12 for period of 3 months at 400C/75 %RH. Finally it was observed that there was no change in physiochemical and physical properties as well as in drug release profile even after storage at 45 °C and 75 % for three months.</p>
      </abstract>
      <kwd-group kwd-group-type="author">
        <kwd>Verapamil hydrochloride</kwd>
        <kwd>dimensional stability</kwd>
        <kwd>elementary osmotic tablet</kwd>
        <kwd>stability study.</kwd>
      </kwd-group>
    </article-meta>
  </front>
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