To study the clinical spectrum of occurrence of Fixed Drug Eruptions (FDEs) to different classes of drugs in a tertiary care hospital. Study was conducted by department of Pharmacology, Sri Devaraj Urs Medical College, Kolar for a period of two years. The data was collected from both in and out patients attending to the Dermatology. A total of 94 adverse drug reactions were collected of which 18 were diagnosed as FDEs. Among them 10 were males and 8 females aged between 2- 60 years. Thirteen FDEs were due to NSAIDs and 5 due to antimicrobials. In all these patients the lesions manifested over the extremities, and 10 of them also had it over the lips and 2 patients on genital and oral mucosa respectively. Diclofenac has caused most of the FDEs. Hyperpigmentation is the common presenting feature. Dechallenge and therapeutic rechallenge was observed in all the patients.