The plant Gmelina arborea has been traditionally used in India for several medicinal purposes like anthelmintic, diuretic, antibacterial, antipyretic, antioxidant and antidiabetic. The aim of the present study is to explore the antipyretic activity of G. arborea fruit extracts using ethanol, ethyl acetate, n-butanol and petroleum ether as solvents. The antipyretic activity was evaluated by inducing fever in experimental animals by injection of Brewer’s yeast at single dose of 300 mg/Kg, b.w. All data are verified for statistically significant by using one way ANOVA at 1 % level of significance (p < 0.01). All extracts showed antipyretic activity at 300 mg/Kg b.w., and the activity is well comparable with the standard drug, Aspirin. Petroleum ether is more effective as compared to other solvent extracts. It could be concluded that G. arborea fruits possess antipyretic activity.