Aeromonas sp. are opportunistic pathogens causing a wide range of diseases including urinary tract infection, peritonitis, gastroenteritis. Special attention was paid to Aeromonas sp. due to its association with a wide range of human illnesses. In the present study a total of 200 Aeromonas sp. were isolated from 350 fish samples. All the isolates were tested for resistance to 10 antibiotics and all the isolates were resistant to methicillin and erythromicin, 97% to rifampicin, 91% to vancomycin, 85% towards trimethoprim, 82% towards cefaperazone, 81% to cefamendole, 62% towards tetracycline, 58% to chloramphenicol and 59% to gentamicin. The least percentage of the resistance was shown towards chloramphenicol. The multiple antibiotic resistance indexing of Aeromons sp showed that all of them originated from high risk sources.