Psychoses are among the most severe psychiatric disorders. In Schizophrenia there is splitting of perception and interpretation from reality-hallucinations, inability to think coherently. The atypical antipsychotics are widely prescribed based on the perception that they are more effective and produce fewer side effects than the typical antipsychotic. The aim is to study the drug utilization of use of atypical antipsychotics in the inpatient of psychiatry department of a tertiary care teaching hospital. All 131 schizophrenic patients hospitalized during the six month period in 2012 were included in the study. Most commonest antipsychotic prescribed was Olanzapine. In our study antipsychotic polypharmacy 95 (72.5%) was seen in majority of patients. Polypharmacy with atypical antipsychotics is on the rise.