Sandhivata is briefly described in Ayurvedic texts. In Charaka Samhita the disease is first described as Sandhigata anila, but Sandhivata is not described in 80 types of Nanatmaja vata vyadhi. Depending upon its symptoms it can be correlated with Osteoarthritis. Osteoarthritis is most common degenerative joint disorder of idiopathic etiology. Secondary OA is pathologically indistinguishable from idiopathic OA. It begins asymptomatically in the second and third decades and is extremely common by age 70. Females are prone with 25% prevalence, whereas males have a prevalence of 16%. In this study 80 patients fulfilling the diagnostic criteria were selected and divided in two groups. In first group Patients were administered with 500 mg capsule of Shallaki, 2 g per day (in two divided doses) with lukewarm water (n=40). In second group patients were administered capsule of Shallaki, 2 g per day (in two divided doses) and Ksheerbala Tail Matra basti simultaneously. After the course of therapy highly significant result were observed in both groups but results were more promising in Second Group (n=40). Key words: Sandhivata , osteoarthritis, Shallaki, Matra basti, degenerative joint disease.