Lupus Nephritis, Systemic Lupus Erythematosus, Cyclophosphamide, Urinary Tract Infection and Pancytopenia.

Lupus nephritis occurs about 30-40% of adult with Systemic Lupus Erythematosus and associated with increased morbidity and mortality. Focal and diffuse proliferative forms of lupus nephritis are known to progress to chronic renal failure unless treated by immunosuppressive drugs. Lupus nephritis remains a major cause of deaths among patients of Hispanic and African-American ethnicity. Generally renal involvement is more common in blacks, Indians and Chinese, with less prevalence Caucasians and Arabs. Cyclophosphamide and glucocorticoids are considered to be the standard care for the patients with proliferative lupus nephritis. Intravenous Cyclophosphamide use is limited due to its potentially severe toxic effects. Here we report a case of Cyclophosphamide induced recurrent occurrence of Urinary Tract Infection and Pancytopenia in lupus nephritis patients and it was treated by using the Mycofenolate Mofetil and Prednisolone.