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  <front>
    <journal-meta>
      <journal-title-group>
        <journal-title>American Journal of Pharmacy and Health Research</journal-title>
        <abbrev-journal-title abbrev-type="publisher">AJPHR</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="epub">2321-3647</issn>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">AJPHR306017</article-id>
      <title-group>
        <article-title>Development and Validation of Common RP-HPLC Method for Estimation of Selected Triptans</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>K.Veditha</surname>
            <given-names>K.Veditha</given-names>
          </name>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>T.E.G.K.Murthy</surname>
            <given-names>T.E.G.K.Murthy</given-names>
          </name>
          <xref ref-type="aff" rid="aff2"/>
        </contrib>
      </contrib-group>
      <aff id="aff1">Vignan Pharmacy College, Vadlamudi, Guntur District, Andhra Pradesh.</aff>
      <aff id="aff2">Bapatla College of Pharmacy, Bapatla, Guntur District, Andhra Pradesh.</aff>
      <pub-date pub-type="epub" iso-8601-date="2015-06-01">
        <month>06</month>
        <day>01</day>
        <year>2015</year>
      </pub-date>
      <volume>3</volume>
      <issue>6</issue>
      <abstract>
        <p>This paper describes the common analytical method suitable for the estimation of selected triptans (Naratriptan, Sumatriptan succinate, Zolmitriptan) by reversed phase high performance liquid chromatography (RP-HPLC). Chromatographic separations were conducted on Phenomenex Luna, C18 250 X 4.6 mm, 5 microns column at room temperature using 6.8 pH phosphate buffer: acetonitrile (60: 40) as a mobile phase at a flow rate of 1.0ml min-1, while UV detection was performed at 225nm. The retention time was found to be 3.130, 3.153, 2.143min respectively for the selected triptans. The method was found to be linear in the range of 2-10µg ml-1 for all the drugs. The proposed method is having good sensitivity due to low LOD and LOQ values. Analytical recovery was &gt;99.3%. The method was validated statistically and applied for the quantitative analysis of triptans in bulk and formulations.</p>
      </abstract>
      <kwd-group kwd-group-type="author">
        <kwd>Triptans</kwd>
        <kwd>RP-HPLC</kwd>
        <kwd>analytical method</kwd>
        <kwd>validation.</kwd>
      </kwd-group>
    </article-meta>
  </front>
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