Resveratrol is a polyphenol found in grapes and red wines. Interest in this polyphenol has increased due to its pharmacological cardio- and neuroprotective, chemopreventive, and antiaging effects, among others. Nevertheless, its pharmacokinetic properties are less favorable, since the compound has poor bioavailability, low water solubility, and is chemically unstable. To overcome these problems, we developed two novel resveratrol nanodelivery systems based on lipid nanoparticles to enhance resveratrol’s oral bioavailability for further use in medicines, supplements, and nutraceuticals. Solid lipid nanoparticles (SLNs) and nano structured lipid carriers (NLCs) loaded with resveratrol were successfully produced by homogenization and ultrasonication technique. These were completely characterized for particle size, zeta potential, DSC and TEM, to evaluate the quality of the developed resveratrol-loaded nanoparticles. The in vitro release studies showed that both the nanosystems are highly stable system allowing sustained and controlled release after uptake.