The abuse of antimicrobials in the treatment procedures is the sole cause of emerging resistant strains of the common pathogen. Present study was intended to monitor the Methicillin Resistance and the antibiotic resistance pattern among the Staphylococcus aureus isolated from clinical specimens.  The antibiotic disc diffusion assay was used to study the resistance pattern. The confirmation of MRSA was done using cephoxitin 30 µg disc. The overall isolation rate of Staphylococcus aureus from different clinical samples was found to be 65.46% and showed dominance in clinical samples collected from males. Methicillin resistant Staphylococcus aureus (MRSA) were detected at the rate of 43.36%. The recovery of MRSA was found to be higher in female gender. The highest resistance of Staphylococcus aureus was seen against the penicillin & ampicillin antibiotics; however the vancomycin, chloramphenicol, tetracycline and ofloxacin showed higher sensitivity. The study concludes that, the S. aureus acquired resistance to frequently used drugs and becomes major threat in its therapeutic management. Study recommends proper use of antibiotics to avoid the emergence of the drug resistant strains and the searching of new antimicrobials for controlling the resistant strains in urgency.