Dandy-Walker Malformation is characterized by triad of Hypoplasia of vermis, Fourth ventricular cystic dilatation and tentorium cerebelli elevation. It is a rare anomaly of cerebellum which is commonly associated with other chromosomal disorder like Trisomy 13. The ultrasound is very critical and diagnostic imaging modality for diagnosis during antenatal period. We report a case of Dandy-Walker malformation with association of Cleft lip/Cleft palate; posterior spinal defect with myelomeningocele, colpocephaly; and other congenital defects that was diagnosed during a first routine prenatal ultrasound at 21 weeks of gestation. Keywords: Dandy-Walker Malformation, Antenatal ultrasonography, Posterior fossa, Cyst herniation, Occipital meningoencephalocele, Posterior spinal defect with myelomeningocele, Cleft lip/palate