Antiretroviral agent (ARVs) has predictable toxicities and adverse effects because they are most chronically administered drugs. It is essential that clinicians noticeably understand ADRs, eagerly identify them in patients and manage them successfully. Information on adverse drug reactions (ADRs) associated to antiretroviral (ARV) use in public health practice is signifying the requirement for ART safety surveillance in clinical care. In this article, we review the adverse effects of HAART therapy, with definite concentration to the issues and factors deciding adverse drug reactions. Our aspire is to assist physicians achieve a working knowledge of these adverse effects, with the definitive purpose of improving the tolerability and effectiveness of HIV treatment, promoting the early identification and setback of potentially serious adverse effects, and dropping the potential for adverse drug interactions.