Typhoid fever (Enteric fever) is a serious life-threatening illness caused by mostly Salmonella Typhi and also by Salmonella Paratyphi to a lesser extent. This study was carried out to isolate, identify Salmonella spp. from the blood samples of patients who were suspected of suffering from typhoid fever and to determine the antibiotic susceptibility pattern of the selected Salmonella spp. Salmonella spp. was detected in 122 of 1167 samples. Among which 87 (77.68%) were Salmonella Typhi and 25 (22.32%) were Salmonella Paratyphi. The most susceptible age group for Salmonella spp. is 21-30 years. Males (67.86%) are mostly infected by Salmonella spp. than females (32.14%). Salmonella Typhi (77.68%) was found as the predominant etiological agent of typhoid fever followed by Salmonella Paratyphi (22.32%) in our study. Salmonella spp. were resistant against Nalidixic acid, Co-trimoxazole and Pipercillin but sensitive against Ceftriaxone, Imipenem, Meropenem, Amikacin, Cefixime, Ceftazidime, Gentamicin, Cefotaxime. From this study, it can be concluded that these third generation antibiotics still can be used as effective drugs for the treatment of typhoid fever.