This study was done to compare the anti-inflammatory efficacy of prednisolone acetate 1% and difluprednate 0.05% eye drops in the management of ocular inflammation after uneventful small incision cataract surgery. It was a prospective randomized control study done in Department of Ophthalmology, Government Medical College & associated group of hospitals, Kota. 100 patients (age >50 years) with senile cataract were taken. After surgery, 50 patients were treated with prednisolone acetate 1% and 50 patients with difluprednate 0.05% eye drops. Patients were examined and compared on postoperative day 1, 3, 7 & 28 for pain, circumcorneal congestion, corneal oedema, aqueous flare, visual acuity and intraocular pressure. Reduction in pain, ciliary congestion, corneal oedema and aqueous flare on day 7 was more in difluprednate group. No clinically significant elevation in intraocular pressure was noted in any patient during study. Difluprednate 0.05% controls postoperative inflammation rapidly as compared to prednisolone acetate 1%.