This work was carried out to investigate the lipid profile level in ethyl acetate extract of Ganoderma lucidum and atorvastatin in normal and alloxan induced diabetic mice.  Ganoderma lucidum and atorvastatin have shown to reduce LDL level 10.4 and 14.59%, TC level 06.76 and 09.78%, TG level 07.40 and 09.82% alongside equipotently increased HDL level to 09.33 and 15.18% respectively in normal mice. However, in case of diabetic mice, these values were 11.61 and 14.46% for LDL, 10.56 and 13.00% for TC, 10.38 and 13.96% for TG, 14.94 and 20.02% for HDL as well. Therefore, these results suggested that, intra peritoneal administration of Ganoderma lucidum have significantly (p