The aim of the present study is to evaluate the effect of ethanolic extract of Leptadaenia reticulata for immunomodulating activity. The ethanolic extract of plant of Leptadaenia reticulata holds potential as a protective agent against cytotoxic drugs. The extracts when studied on humoral and cell mediated immunity in normal, as well as cyclophosphamide induced immunosuppressed rats. It produced both increase for some parameters and decrease response in some other parameters. The present investigation established pharmacological evidence to support the folklore claim that it is an immunomodulating drug plant.