Liver is the largest gland in the human body. Liver performs various vital functions in our system. The liver breaks down toxic substances and most metals products in a detoxifying manner. The present study was conducted to evaluate the hepatoprotective effects of an alcoholic leaf extract of Annona squamosa on Arsenic Trioxide induced liver damage in albino rats. Wistar albino rats weighing around 180-200g were used. Blood and liver tissue were collected for the assessment of serum marker enzymes such as ALT, AST and ALP.