American Journal of Pharmacy and Health Research

AJPHR

2321-3647

10.5281/zenodo.20156106

AJPHR4140001

Détermination of effect of Ethanolic extract of Gomphrena Celosioides on markers of cellular immunity

Konan

Dr GOGAHY

Germain

Dr Vanié Bi Irié

Patrice

Dr MIEZAN Bilé Aka

Félix

Prof Yapi Houphouet

Justin

Prof SAKI Suomion

Biochemistry Laboratory, Faculty of Biological Sciences, Péléforo GON Coulibaly University of Korhogo, Côte d'Ivoire. Biotechnology, Agriculture and Biological Resource Valorization Laboratory, Faculty of Biosciences, FELIX Houphouet Boigny University of Abidjan Cocody. - Côte d'Ivoire Biochemistry Laboratory, Faculty of Biological Sciences, Péléforo GON Coulibaly University of Korhogo, Côte d'Ivoire Laboratory of Biochemical Pharmacodynamics, Faculty of Biosciences, Felix Houphouet Boigny University of Abidjan Cocody.

04 27 2026

14 4 1 9

ABSTRACT Gomphrena celosioides is a plant used in many traditional medicine recipes in West Africa, Southeast Asia, and South America. The present study aimed to evaluate the cellular immune response induced by the ethanolic extract of Gomphrena celosioides. The acute toxicity study of the extract used, conducted in rats according to OECD guideline no. 423, showed that the extract is non-toxic. The effect of the extract on cellular immunity markers was obtained in rats by measuring white blood cells, CD4+ T lymphocytes, neutrophils, and total lymphocytes. The absolute counts of these cells were determined by flow cytometry phenotyping. This study showed that the ethanolic extract of Gomphrena celosioides significantly increases the number of white blood cells, neutrophils and CD4+ T lymphocytes, thus suggesting an immunostimulatory action of this extract in rats. Keywords: Gomphrena celosioides, ethanolic extract, acute toxicity, cellular immunity markers, immunostimulant

Gomphrena celosioides ethanolic extract acute toxicity cellular immunity markers immunostimulant