Back ground: Many studies carried out to determine the effect of Posioning on the success of implantation, poisoning is an important cause of mortality& morbidity rate in India. The objective of the study was to determine the demographic profile and mode of poisoning of patients & determine the exposure and outcome of patients. And also to asses the oxidative damage, hemoglobin levels  & leucocyte count in Posioning cases. Methods :It is retrospective type of design. The cholinestrase levels was  assessed by  the toxicity markers& also oxidative damage was assessed by the estimating the serum aldehyde levels, glutathione peroxidase levels. The significant decline  in choline straese correlation with the severity of poisoning was observed. The over all 157 cases of poisoning were reviewed retrospectively in tertiary care hospital. Among them, 153 cases were of intentional poisoning and rest 4 cases were accidental poisoning: The results of the present study suggested that the young age people with the age of 21 to 30 were more prone to suicide, particularly male in this age group. Most of them have used Organo phosphorous pesticides for committing suicide.