In the present study ethanolic and aqueous extracts of the whole plant of Leonotis nepetifolia (L). R.Br. were investigated for their anthelmintic activity against Pheretima posthuma. Three concentrations (25, 50 and 75 mg/ml) of each extract were subjected for evaluation. The study is mainly concerned with the determination of time of paralysis and time of death of the worm. The gradual increase in the dose showed a gradual increase in the anthelmintic activity. The ethanolic extract of the whole plant showed a significant anthelmintic activity at highest concentration of 75 mg/ml in shorter time as near to Albendazole (Standard drug).