Immunity is the protective response of our body to the antigen. The traditional Indian system of medicine (Ayurveda) describes different methods involved in the prevention and treatment of disease which are consequence of diet, life style and drugs as cornerstones of therapy. Herbal products are known to modify different aspects of human physiology and exert an alleviating influence on several patho-physiological states including modulation of immune system. In recent years, studies on evaluation of the therapeutic and toxic activity of herbal medicinal products became available and popular. Several herbs have proven immuno-modulating effects in severe conditions like HIV. Present review summarizes different data with respect to herbal immuno-modulators in various disease conditions.