Diabetic Milletus(DM).is the most frequent endogenous cause of fat metabolism- disorder. Therefore, the study aims to monitor the lipid profile  in  DM type 2 patients controlled and uncontrolled in Sana’a , Yemen. The study included 150 subjects from major public hospitals in Sana'a city, Yemen. 50 were diagnosed with DM type 2 controlled as group I and 50 were diagnosed with DM type 2 uncontrolled as group II. 50 subjects were healthy volunteers as control group. The biochemical parameters namely Fasting Blood Sugar (FBG) , and Glycelated Hemoglobin (HBA1c) were assayed in three groups. Data obtained were analyzed using suitable statistical tools. The lipid profile namely total cholesterol  mg/dl , triglyceride mg/dl HDL mg/dl, and LDL mg/ were assayed in DM type 2   controlled and uncontrolled and compared with control healthy group. The results were  described namely (166 ± 31 mg/dl ; 196 ± 50 ; 131 ± 28 ) , (146± 60 mg/dl ; 193 ± 94 ; 92 ± 30 ) , (37± 8.2 mg/dl , 36 ± 14, 42 ± 12 ), and (80 ± 25 mg/dl , 95 ± 30 , 76 ± 25) respectively.   According to above results , non different significant (p > 0.05) in all parameters of lipid profile was observed between DM  type 2  controlled and uncontrolled groups . while the results were observed different significant (p < 0.05) in serum levels of total cholesterol , triglyceride and LDL between controlled and healthy group and also non - different significant (p > 0.05) in serum levels of HDL between both . In addition, different significant (p > 0.05) in all parameters of lipid profile was observed between uncontrolled and control healthy groups .The study outcome concluded  that the hyperlipidemia may progressive in DM type 2 patients uncontrolled.