The term Ziabetus Shakri is being used for Diabetes Mellitus in Unani System of Medicine; considered as metabolic disorder at various levels. The disease is classified as; (1) Type 1 Diabetes Mellitus (2) Type 2 Diabetes Mellitus. In former type body is absolutely unable to produce insulin while in later type body produce either insufficient insulin or glucose metabolism in the body refracts insulin. Both are metabolic disorder but type 2 has a greater relation with other metabolisms of the body than Type 1. No doubt in the modern era new drugs, better insulin, and superior monitoring techniques have been developed but cost and side effects of these interventions cannot be isolated. This is the reason to have a look on other systems of medicine which are helpful not only in controlling of the disease but also modifying its risk factors and improving quality of life. Unani System of Medicine which is one of the oldest and most popular systems of medicine can deal with this dangerous and life threatening disease in a very systemic and optimal way. In this paper an attempt has been made to explore the physiopathology of the disease and accordingly its management by Unani System, of Medicine.