ABSTRACTPrescribing pattern monitoring studies are a tool for assessing the prescribing, dispensing and distribution of medicines. The main aim of this study is to facilitate rational use of medicines. Diabetes is a metabolic disorder characterized by the existence of hyperglycaemia due to malfunctioning insulin secretion, insulin action or both. The main aim of this study is to study the prescribing pattern of anti-diabetic drugs in a Type-II diabetes mellitus in a tertiary care teaching hospital. This Prospective observational study performed for a period of 6 months in general medicine department Rajiv Gandhi Institute of Medical sciences. A total 320(100%) patients were recruited under inclusion criteria upon taking of ICF based on inclusion and exclusion criteria. In this study we found a higher incidence in age group of 45-65 years. Mean age of patients came out to be 57.36 ± 8.80 years. Average number of drugs per prescription was 3.99 because of polypharmacy practice in diabetic patients. Biguanides and Sulfonylureas are the most commonly prescribed antidiabetic drugs that were in line with other studies. Among biguanides metformin was most commonly prescribed drug. Maintaining better glycemic control is a therapeutic goal for Type 2 DM patients, which can reduce the frequency of complications and thereby improves quality of life. A strong conclusion of this study highlights the necessity for patient education and counselling on usage of antidiabetic and associated drugs, regular checkups of blood glucose and glycosylated haemoglobin (HbA1c) levels, dietary changes with low calorie food, and rectification of diabetic problems. Keywords: Prescribing pattern, diabetes mellitus, rational use of drugs, better patient care.