ABSTRACTImmunization has been one of the most significant, cost-effective and stimulatory public health interventions. India, along with the whole world, stands committed to the welfare of children, as reflected in the theme of 'World Immunization week, 2017,' viz. ‘Vaccines work’. The early twentieth century witnessed the challenges in expansion of different diseases i.e. Polio, DPT etc. in all of the Indian states. Despite a lot of reduction in disease burden of vaccine preventable diseases through childhood immunisation, considerable progress needs to be made in terms of ensuring efficiency and equity of vaccination coverage. In India according to National Family Health Survey (NFHS-4) factsheets at least 6 out of 10 children have received full immunisation in 12 out of 15 states/union territories which can be considered quite high from the findings of complete immunisation in NFHS-3 i.e. 44% only. Keywords: Immunisation, NFHS-4, Vaccination, Infant mortality, Disease burden.